Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury
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چکیده
منابع مشابه
Relationship between peroxisome proliferator-activated receptor-γ and renal ischemia-reperfusion injury.
The pathogenesis of ischemia-reperfusion (I/R) injury is known to involve cytokines and, in particular, surface adhesion molecules, the expression of which initiates inflammatory cell attachment. It has been suggested that peroxisome proliferator-activated receptor (PPAR)-γ is an important immunomodulatory factor as well as a regulator of fatty acid. In this study, we investigated the expressio...
متن کاملPeroxisome proliferator-activated receptor-alpha contributes to the resolution of inflammation after renal ischemia/reperfusion injury.
This study was designed to elucidate the role of peroxisome proliferator-activated receptor (PPAR)-alpha in the development of inflammation after ischemia/reperfusion injury of the kidney. We have evaluated the effects of ischemia/reperfusion on renal dysfunction, injury, and inflammation in wild-type mice or mice in which the gene for PPAR-alpha has been deleted [PPAR-alpha(-/-)] and then trea...
متن کاملAgonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury.
BACKGROUND/AIMS Recent evidence indicates that peroxisome-proliferator activated receptor (PPAR) agonists protect against ischemia/reperfusion (I/R) injury. Here we investigate the effects of the PPAR-gamma agonists, rosiglitazone and ciglitazone, on the renal dysfunction and injury caused by I/R of the rat kidney in vivo. METHODS Rosiglitazone or ciglitazone were administered to male Wistar ...
متن کاملPeroxisome Proliferator-Activated Receptor- Contributes to the Resolution of Inflammation after Renal Ischemia/Reperfusion Injury
This study was designed to elucidate the role of peroxisome proliferator-activated receptor (PPAR)in the development of inflammation after ischemia/reperfusion injury of the kidney. We have evaluated the effects of ischemia/reperfusion on renal dysfunction, injury, and inflammation in wild-type mice or mice in which the gene for PPARhas been deleted [PPAR( / )] and then treated with the PPARago...
متن کاملThe Role of Peroxisome Proliferator Activator Receptor Alpha in Cerebral Ischemia-Reperfusion Injury; a Review Study
Peroxisome proliferator-activated receptor alpha (PPAR-α), which belongs to the nuclear receptor family of ligand-activated transcription factors, was first described as gene regulators for metabolic pathways including lipid metabolism, insulin sensitivity, and glucose homeostasis. Were raised. This nuclear receptor is widely expressed in various tissues, providing a wide range of effects to st...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2008
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.1.4.499